Flow Cytometry catalog - US 2019

Single-Color Conjugated Antibodies

Analyte Specific Reagents - ASR product list

CD146 The CD146 molecule, also known as S-Endo, is a single chain transmembrane glycoprotein with a molecular weight of 118 kDa, belonging to the immunoglobulin superfamily (IgS). The extracellular structure consists of five Ig-like domains: two V-type, and three C2-type Ig-like domains. The CD146 antigen is related to cell adhesion molecules of the IgS family and its presence is concentrated at regions of cell-cell contact, confirming its role in adhesion and particularly in maintenance of monolayer integrity. CD146 is constitutively expressed in the endothelium, and is also observed on other cell types such as smooth muscle cells, and intermediate trophoblasts. Among peripheral whole blood leucocytes, CD146 expression is not detected, except on a subset of activated T-lymphocytes.

HELA Cell line.

Clone: TEA 1/34

Isotype: IgG2a Mouse

The TEA 1/34 monoclonal antibody was assigned to the CD146 (Code: E077) during the HLDA 6.

Form

Size

Format

Part#

Status

Line Quality Standard

PE

A07483 A22364

2 mL 1 mL

Liquid Liquid

ASR ASR

IOTest IOTest

GMP GMP

PC5

CD154 The CD154 antigen (CD40-ligand), also known as TRAP (Tumor necrosis factor Related Activation Protein), is a member of the Tumor Necrosis Factor (TNF) superfamily. It is a 32 kDa type II transmembrane molecule. CD154 is rapidly induced on T cells (CD4+ and some CD8+ cells) following TCR activation. First identified on activated T cells, CD154 is also expressed on platelets, as well as monocytes and B cells. CD154 can also be shed from activated platelets and lymphocytes in a soluble form (sCD154). This ligand for the CD40 molecule is present on some basophils and mast cells. It has critical regulatory roles in T- and B-lymphocyte function. CD40/CD154 interaction is essential for the development of thymus-dependent humoral immune responses. Ligation of CD40 on B cells by CD154 on T cells promotes B cell proliferation, immunoglobulin (Ig) production, isotype switching and memory B-cell generation.

P3XTBA7 Cell line.

Clone: TRAP-1

Isotype: IgG1 Mouse

The TRAP-1 antibody inhibits activation induced by full-length soluble human CD154.

Form

Size

Format

Part#

Status

Line Quality Standard

PE

IM2216U

2 mL

Liquid

ASR

IOTest

GMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 88 US Clinical Diagnostics Catalog