Flow Cytometry catalog - US 2019

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Single-Color Conjugated Antibodies

Analyte Specific Reagents - ASR product list

CD105 The CD105 antigen, also called Endoglin, is a 170-180 kDa RGD containing molecule which is present on the cell surface as a disulphide-linked homodimer. The molecule is a co-receptor for Transforming Growth Factor (TGF) β 1 and β 3. It is expressed mainly on endothelial cells, but also strongly in pre-B lymphocytes and in a subpopulation of monocytes. CD105 is a regulatory protein of TGF-beta receptor complex. CD105 expression and function in primitive hematopoiesis indicate that this molecule could cooperate with the dissociation of TGF- β 1 cell cycle effects from its other effects on cell survival and differentiation.

Form Clone: TEA3/17.1.1

Isotype: IgG1 Mouse

Size

Format

Part#

Status

Line Quality Standard

B76299 B43293

1 mL

Liquid Liquid

ASR ASR

IOTest IOTest

GMP GMP

PC7

0.5 mL

CD107a ( LAMP-1 ) The CD107a antigen is the heavily glycosylated 110 kDa lysosomal-associated membrane protein, LAMP-1. Together with LAMP-2, they are the mayor glycoproteins on the membrane of lysosome granules. CD107a molecule is ubiquitously found as intracellular antigen. It is also expressed on the surface of activated platelets, PHA activated, a few monocytic cell lines, and fetal thymus stromal cells. It has been described as a marker of cytotoxic CD8+ Tcell degranulation and of NK cell functional activity. As platelet activation marker, it has characteristics of an adhesive molecule. A minor fraction (<2%) of LAMP-1 is associated with the plasma membrane of most nucleated cells, presumably as a result of selective exchange of lysosomal and plasma membranes. Increased surface expression of LAMP-1 has been observed on transformed cells of high metastatic potential, and on embryonic cells.

Lysed normal whole blood sample gated on NK cells.

Form Clone: H4A3