Flow Cytometry catalog - US 2019

Single-Color Conjugated Antibodies

Analyte Specific Reagents - ASR product list

CD4 The CD4 antigen is a monomeric transmembrane glycoprotein with a molecular weight of 59 kDa. The intracytoplasmic tail of CD4 is essential for interaction with Lck. The CD4 is expressed on the T "helper" (Th or T4) lymphocytes. It is expressed on most thymocytes, where it is frequently co-expressed with CD8. CD4 is also expressed on eosinophils. All the monocytes carry the CD4 antigen, but at a lower density than T4 lymphocytes. CD4 acts as an accessory molecule to the T cell receptor complex during T-cell activation restricted to the major histocompatibility complex class II. The T4 lymphocytes are involved in T-T, T-B, and B- macrophage cellular interactions. They are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 functions as the receptor for IL-16 which is a chemoattractant factor for CD4+ T cells, as well as for monocytes and eosinophils. IL-16 seems to be a growth factor for T4 lymphocytes, but is not able to induce cell division. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120. Isotype: IgG1 Mouse 13B8.2 monoclonal antibody antagonizes HIV effects in vitro . 13B8.2 recognizes an epitope close to the amino-acid residues 88-89 within the CD4 molecule. 13B8.2 and BL4 recognize different epitopes. 13B8.2 and BL4 are not cross- blocking. Clone: 13B8.2

Lysed normal whole blood sample.

Form

Size

Format

Part#

Status

Line Quality Standard

PB

A82789 A96417 IM0448U IM0449U IM2636U IM2468U B10824 A94685 IM0704 IM0398 B16491

0.5 mL 0.5 mL

Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid

ASR ASR ASR ASR ASR ASR ASR ASR ASR ASR ASR

IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest

GMP GMP GMP GMP GMP GMP GMP GMP GMP GMP GMP

KrO FITC

2 mL 2 mL 1 mL

PE

PC5

PC5.5

0.5 mL

APC

1 mL

APC-A700 APC-A750

0.5 mL 0.5 mL 0.2 mg 0.2 mg

Biotin UNLB

Freeze-dried Freeze-dried

- -

Clone: SFCI12T4D11 (T4)

Isotype: IgG1 Mouse

Form SFCI12T4D11 monoclonal antibody antagonizes HIV effects in vitro . Part# Format Size

Status

Line Quality Standard

ECD

6604727

CYTO - STAT

0.5 mL

Liquid

ASR

GMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 36 US Clinical Diagnostics Catalog