Flow Cytometry catalog - US 2019

Single-Color Conjugated Antibodies

In Vitro Diagnostic Products & CE-marked Products - IVD/CE product list

CD4 The CD4 antigen is a monomeric transmembrane glycoprotein with a molecular weight of 59 kDa. The intracytoplasmic tail of CD4 is essential for interaction with Lck. The CD4 is expressed on the T "helper" (Th or T4) lymphocytes. It is expressed on most thymocytes, where it is frequently co-expressed with CD8. CD4 is also expressed on eosinophils. All the monocytes carry the CD4 antigen, but at a lower density than T4 lymphocytes. CD4 acts as an accessory molecule to the T cell receptor complex during T-cell activation restricted to the major histocompatibility complex class II. The T4 lymphocytes are involved in T-T, T-B, and B-macrophage cellular interactions. They are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 functions as the receptor for IL-16 which is a chemoattractant factor for CD4+ T cells, as well as for monocytes and eosinophils. IL-16 seems to be a growth factor for T4 lymphocytes, but is not able to induce cell division. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120.

Clone: SFCI12T4D11 (T4)

Isotype: IgG1 Mouse

Form SFCI12T4D11 monoclonal antibody antagonizes HIV effects in vitro . Part# Format Size

Status

Line Quality Standard

FITC FITC

6602393 6603862 6602864 6603850

Freeze-dried 100 tests

IVD & CE IVD & CE IVD & CE IVD & CE

GMP GMP GMP GMP

COULTER CLONE

CYTO - STAT

50 tests 100 tests 50 tests

Liquid Liquid Liquid

RD1 RD1

COULTER CLONE

CYTO - STAT

CD8 The CD8 antigen is a disulfide-linked dimer, which exists either as a CD8 α homodimer or as a CD8 α / β heterodimer. CD8 α is required for surface expression of CD8 β . The molecular weight of each monomer of α or β is approximately 32-34 kDa. CD8 binds to a non-polymorphic domain ( α 3 domain) of MHC Class I molecules. CD8 is expressed on a subset of human peripheral blood T lymphocytes. A subset of NK cells possess the CD8 antigen but show low to medium density of expression. CD8 α homodimer is expressed by NK cells and γ / δ + T cells. CD8 is also present on most thymocytes where it is frequently co- expressed with CD4, and on a subpopulation of bone marrow cells. The CD8 molecule acts with the T Cell Receptor (TCR) as a coreceptor for MHC class I restricted antigen recognition. CD8 is widely used as a marker of cytotoxic T lymphocytes.

Clone: SFCI21Thy2D3 (T8)

Isotype: IgG1 Mouse

Form SFCI21Thy2D3 monoclonal antibody recognizes the α chain of the CD8 molecule. Part# Format Size Status

Line Quality Standard

FITC FITC

6602385 6603861 6603274 6603848

Freeze-dried 100 tests

IVD & CE IVD & CE IVD & CE IVD & CE

GMP GMP GMP GMP

COULTER CLONE

CYTO - STAT

50 tests 100 tests 50 tests

Liquid Liquid Liquid

RD1 RD1

COULTER CLONE

CYTO - STAT

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 30 US Clinical Diagnostics Catalog