Flow Cytometry catalog - US 2019

Single-Color Conjugated Antibodies

In Vitro Diagnostic Products & CE-marked Products - IVD/CE product list

CD2 The CD2 antigen (also called LFA-2 or T11 antigen) is a 50 kDa single chain type I transmembrane glycoprotein that comprises two external domains belonging to the immunoglobulin superfamily (IgSF). It was formerly described as the sheep red blood cell receptor, causing T-cell rosetting. Signaling molecules, such as Fyn, Lck and the PI3-kinase, have been reported to associate with the intracellular domain of CD2. CD2 has been identified as the ligand for CD58 (LFA-3). It is also a receptor for CD48, CD59 and CD15. The CD58-CD2 interaction is a component of intercellular adhesion and costimulatory signaling in T cells. CD2 is involved in the regulation of human T-cell cytokine production, and in a Fas-independent induced apoptosis of activated human peripheral T cells. CD2 is present on all human non-B peripheral lymphocytes, on the majority of thymic T cells, and on a subset of thymic B cells.

Clone: SFCI3Pt2H9 (T11) Isotype: IgG1 Mouse SFCI3Pt2H9 inhibits sheep erythrocyte rosette formation. It has been used as a CD2 reference monoclonal antibody during HLDA 6 (ref.6T-CD2.6).

Form

Size

Format

Part#

Status

Line Quality Standard

FITC

6602389 6602868

Freeze-dried 100 tests

IVD & CE IVD & CE

GMP GMP

COULTER CLONE

RD1

100 tests

Liquid

COULTER CLONE

CD3 CD3 ζ see TCR ζ .

The CD3 antigen is a complex of 5 invariable polypeptidic chains: γ , δ , ε , ζ and η , whose molecular weights are respectively 25 -28, 21, 20, 16 and 22 kDa. The CD3 chains are clustered in a group of two invariant dimers, γ / ε and δ / ε associated with a variable dimer which consists of ζ homodimers, or ζ / η , or ζ / γ FcR heterodimers ( γ FcR being the γ chain of the Fc receptors), or γ FcR homodimers. The CD3 is part of a bigger complex which includes the T Cell Receptor (TCR). CD3 complex associated with the TCR is involved in the recognition of peptides bound to the major histocompatibility complex class I and II during the immune response. T cell activation may be induced when a foreign antigen is presented to the TCR through MHC complex. The CD3 antigen is expressed by mature T lymphocytes and by a subset of thymocytes.

Clone: UCHT1 Isotype: IgG1 Mouse UCHT1 reacts with the ε -chain of the CD3 complex. It was used as a CD3 reference mAb (ref.6T-CD3.1) during HLDA 6. After permeabilization with saponin-based permeabilization reagent IntraPrep, it may be used to detect intracytoplasmic CD3 by flow cytometry.

Form

Size

Format

Part#

Status

Line Quality Standard

FITC FITC

6604623 6604625 6604621 6604627

CYTO - STAT

50 tests

Liquid

IVD & CE IVD & CE IVD & CE IVD & CE

GMP GMP GMP GMP

Freeze-dried 100 tests

COULTER CLONE

RD1 RD1

CYTO - STAT

50 tests 100 tests

Liquid Liquid

COULTER CLONE

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 29 US Clinical Diagnostics Catalog