Flow Cytometry catalog - US 2019

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Single-Color Conjugated Antibodies

Research Use Only (RUO) Reagents

CD106 The CD106 antigen, also known as Vascular Cell Adhesion Molecule-1 (VCAM-1), is an adhesion molecule which binds to integrin α 4/ β 1 (VLA-4) and integrin α 4/ β 7 on lymphocytes. It is a 110 kDa cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 antigen is present on activated endothelial cells, tissue macrophages, dendritic cells and bone marrow fibroblasts. It is involved in the adhesion of lymphocytes, monocytes and eosinophils to activated endothelium. Recent studies shown that CD106 identifies a unique subpopulation of Mesenchymal Stem Cells (MSCs) with powerful immunosuppressive activity.

HUT78 Cell line.

Clone: 1G11

Isotype: IgG1 Mouse

The 1G11 antibody inhibits T lymphocyte adhesion to TNF-stimulated endothelial cells.

Form

Size

Format

Part#

Status

Line Quality Standard

A66085

100 tests

Liquid

RUO

IOTest

GMP

CD109 ( E123 ) The CD109 antigen is a monomeric glycosyl phosphatidylinositol (GPI)-linked glycoprotein of 170 kDa. It is a novel member of the α 2 macroglobulin ( α 2M) / C3, C4, C5 family of thioester- containing proteins. CD109 is found on vascular endothelial cells, some epithelial cells, activated T-cells, activated platelets, leukemic megakaryoblasts and a subset of bone marrow CD34+ cells. It is not expressed on fresh peripheral blood lymphocytes (PBL). Poorly differentiated (CD34+, TdT+, CD7+) T-acute leukemias and rare cases of chronic myeloid leukemia in megakaryoblast crisis express the CD109 antigen. Furthermore, megakaryoblastoid cell lines (MO7e, MOLM-1) are CD109+. The CD109 antigen may represent a very early marker for hematopoietic cells committed to the megakaryocyte lineage. In contrast, the adult bone marrow CD34+ CD109+ subset identifies the most primitive hematopoietic stem cells capable of long-term culture and lymphoid progenitors of the B-cell lineage.

KG1A Cell line.

Form Clone: 8A3

Isotype: IgG2a Mouse