Flow Cytometry catalog - US 2019

Single-Color Conjugated Antibodies

Analyte Specific Reagents - ASR product list

NKp80 The NKp80, also known as killer cell lectin-like subfamily F, member 1 (KLRF1) is a type II transmembrane glycoprotein of 80 kDa and 40 kDa under reducing conditions. It is expressed on NK cells and a subset of T lymphocytes whereas it is not expressed on B lymphocytes, monocytes and granulocytes. The NKp80 antigen is a 231 amino acid protein which belongs to the C-lectin family and is encoded by a gene located on chromosome 12. It is characterized, in its 169 amino acid extracellular domain by 4 glycosylation sites and by two tyrosine residues in its 39 amino acid cytoplasmic domain. The transmembrane domain contains 23 amino acids. The NKp80 molecule binds to the genetically linked receptor AICL which is up-regulated by Toll-like receptor stimulation. NKp80-AICL interaction regulates the immune responses at sites of inflammation by stimulating the release of proinflammatory cytokines.

Lysed normal whole blood sample.

Clone: MA152 Isotype: IgG1 Mouse The monoclonal antibody MA152 recognizes NK cells, a subset of T lymphocytes. It does not react with NK92, NK3.3 and YT cell lines.

Form

Size

Format

Part#

Status

Line Quality Standard

PE

A52635

1 mL

Liquid

ASR

IOTest

GMP

Perforin Perforin is a 70 kD N-glycosylated modified cytolytic protein. Following synthesis and post- translational modifications, perforin monomers are packaged into lysosome-like cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Both types of cells kill their cellular targets by mechanisms that require direct contact between the effector and target cells. Cytoplasmic granule toxins, predominantly perforin, and a family of structurally related serine proteases (granzymes) with various substrate specificities are secreted by exocytosis and together induce apoptosis of the target cell. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.

Lysed normal whole blood sample.

Form Clone: dG9

Isotype: IgG2b Mouse

Size

Format

Part#

Status

Line Quality Standard

PB

B46030

0.5 mL

Liquid

ASR

IOTest

GMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 115 US Clinical Diagnostics Catalog