Flow Cytometry catalog - US 2019

Single-Color Conjugated Antibodies

Analyte Specific Reagents - ASR product list

CD326 ( EpCAM ) CD326 also known as EpCAM (Epithelial Cell Adhesion Molecule) is a 40 kDA type I transmembrane glycoprotein expressed at the cell surface of a variety of epithelial cells. CD326 is a hemophilic Ca2+ independent cell-cell adhesion molecule which plays a major role in intercellular adhesion. Additionally it has been described to play an important role in cell signaling, proliferation, differentiation and maintenance of organ morphology. In the field of oncology, CD326 is a key marker for the isolation and identification of circulating tumor cells.

HT29 cell line

Clone: VU1D9

Isotype: IgG1 Mouse

The monoclonal antibody VU1D9 recognizes an epitope within EGF like domain I of CD326.

Form

Size

Format

Part#

Status

Line Quality Standard

APC

B90408

0.5 mL

Liquid

ASR

IOTest

GMP

CD335 ( NKp46 ) CD335, also known as NKp46, is a 46-kDa transmembrane glycoprotein which is a NK-specific triggering receptor involved in non-MHC-restricted natural cytotoxicity and considered the prototype of the NK natural cytotoxicity receptors (NCRs). Its expression is restricted to all resting and activated NK cells, including the minor CD3–CD56brightCD16– subset. Although CD335 is highly expressed at the NK-cell surface in the majority of donors, some individuals have a proportion of NK cell (which vary up to 90%) expressing a “dull” NKp46 phenotype. CD335 is a member of the immunoglobulin superfamily characterized by two extracellular C2- type Ig-like domains. It is associated with the ITAM bearing molecules CD3 ζ and Fc ε RI γ . Although this association is likely to be essential for signal transduction via NKp46, CD3 ζ is not required for NKp46 surface expression. NKp46 represents a major activating receptor and plays a central role in the lysis and clearance of HLA class I– cells. The magnitude of lysis correlates with its level of surface expression. Isotype: IgG1 Mouse BAB 281-mediated masking of NKp46 molecule inhibits NK cytotoxicity versus different target cells. In redirected killing assays, BAB281 binding to NKp46 induces a strong increase of cytolytic activity. Although hemagglutinins of viral origins have been identified as ligands for NKp46 receptor, the natural (non-viral) ligand for NKp46 is unknown. Clone: BAB281

Lysed normal whole blood sample.

Form

Size

Format

Part#

Status

Line Quality Standard

PE

IM3711

1 mL

Liquid Liquid Liquid

ASR ASR ASR

IOTest IOTest IOTest

GMP GMP GMP

PC5 PC7

A66902 B38703

0.5 mL 0.5 mL

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 104 US Clinical Diagnostics Catalog