Flow Cytometry catalog - ROW 2019

Single-Color Conjugated Antibodies

The CD57 antigen (HNK-1 antigen carbohydrate moiety) is an oligosaccharide with sulfated glucoronic acid residues that may be linked to a variety of polypeptides or lipids. In peripheral blood, it is found on a subset of cells with natural killer activity. It is confined to mononuclear cells, primarily large granular lymphocytes. Many of these CD57+ cells co-express the CD8 antigen and are a subset of the suppressor / cytotoxic T lymphocytes. Cord blood T cells or NK cells lack the CD57 antigen. It is not expressed on red blood cells or on platelets but is present on some neuroectodermal tissues. CD57

Lysed normal whole blood sample

Form Clone: NC1

Isotype: IgM Mouse

Size

Format

Part#

Status

Line Quality Standard

PB

A74779 IM0466U

0.5 mL

Liquid Liquid Liquid

ASR ASR

IOTest IOTest IOTest

GMP GMP

FITC FITC

2 mL

B49188

100 tests

CE

98/79/EC

CD58 is a glycoprotein of 65-70 kDa, either transmembrane or glycosylphosphatidylinositol (GPI)-anchored. CD58 was first described as the lymphocyte-function associated antigen 3 (LFA-3). LFA-3 was further shown to interact with CD2 suggesting an important role in various immunological responses via T-cell adhesion and activation. CD58 activate the costimulation pathways of T lymphocytes and natural killer (NK) cells, maximizing the cytolysis of target cells by cytotoxic T lymphocytes (CTL) and NK cells. This antigen is widely expressed on leucocytes, erythrocytes and endothelial cells. CD58

Lysed normal whole blood sample.

Clone: AICD58 Isotype: IgG2a Mouse The AICD58 antibody is a blocking antibody in LFA-3 mediated adhesion. This antibody was used as a CD58 reference mAb during HLDA 6.

Form

Size

Format

Part#

Status

Line Quality Standard

FITC

IM1218U IM1430 IM3702 IM3701

2 mL 2 mL 1 mL 1 mL

Liquid Liquid Liquid Liquid

ASR ASR ASR ASR

IOTest IOTest IOTest IOTest

GMP GMP GMP GMP

PE

PC5 APC

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 69 Outside US Flow Cytometry Catalog