Flow Cytometry catalog - ROW 2019

Single-Color Conjugated Antibodies

The CD54 antigen, previously known as ICAM-1 (InterCellular Adhesion Molecule-1), is a 90 kDa transmembrane glycoprotein. With seven potential N-linked glycosylation sites, its structure, as that of CD50 (ICAM-3) and CD102 (ICAM-2), is related to the Immunoglobulin family. The CD54 antigen mediates the adhesion of T lymphocytes with Antigen-Presenting Cells (APC) and is involved in T cell to T cell and T cell to B cell interactions. It is also involved in the adhesion of monocytes, lymphocytes and neutrophils to activated endothelium. It binds to the integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It is a receptor for the rhinovirus. It is expressed by endothelial cells and by many other cell types upon activation. CD54

Lysed normal whole blood sample.

Clone: 84H10

Isotype: IgG1 Mouse

84H10 antibody inhibits ICAM-1 mediated adhesion to LFA-1.

Form

Size

Format

Part#

Status

Line Quality Standard

FITC

IM0726U IM1239U

2 mL 2 mL

Liquid Liquid

ASR ASR

IOTest IOTest

GMP GMP

PE

The CD55 antigen is a single chain glycosyl-phosphatidyl-inositol (GPI)-anchored, cell surface protein. This molecule undergoes post-transcriptional and post-translational modification resulting in a heterogeneous molecular weight ranging from 55 to 80 kDa. The CD55 antigen, also named Decay Accelerating Factor (DAF) is involved in the regulation of both alternative and classical complement pathways. C3b/C3Bb and C4b/C4b2a convertases, as well as echovirus, coxsackie B virus and CD97 are reported to interact with CD55. Like other GPI- anchored proteins, CD55 is associated in the cytoplasmic compartment with tyrosine kinases allowing signal transduction. The CD55 molecule is widely expressed on human cells including leucocytes, erythrocytes and platelets. CD55 is weakly expressed on NK cells. CD55

Lysed normal whole blood sample.

Form Clone: JS11KSC2.3

Isotype: IgG1 Mouse

Size

Format

Part#

Status

Line Quality Standard

FITC

IM2725 IM2726 B49190

2 mL 2 mL

Liquid Liquid Liquid

ASR ASR

IOTest IOTest IOTest

GMP GMP

PE PE

100 tests

CE

98/79/EC

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 67 Outside US Flow Cytometry Catalog