Flow Cytometry catalog - ROW 2019

Single-Color Conjugated Antibodies

The CD41 antigen (platelet GPIIb; IIb integrin) is a transmembrane glycoprotein composed of two chains GPIIb α (120 kDa) and GPIIb β (23 kDa) linked by one disulfide bond. CD41 is always non-covalently associated with CD61 (platelet GPIIIa, β 3 integrin), to form the GPIIb-IIIa (CD41/CD61) complex. CD41 is expressed by platelets, megakaryocytes and a small subset of CD34+ cells, suggesting that CD41/CD61 is one of the earliest markers of the megakaryocytic lineage. The resting form of the CD41/CD61 complex binds to immobilized fibrinogen and upon platelet activation, the complex becomes a receptor for soluble fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. It is involved in platelet aggregation. CD41

HEL cell line

Clone: P2 Isotype: IgG1 Mouse The P2 antibody reacts with the α chain of CD41a (GPIIb α ) in the intact complex with GPIIIa but not with the GPIIb or GPIIIa separately. This antibody blocks binding to fibrinogen and inhibits platelet aggregation induced by thrombin, collagen and ADP. The P2 antibody was used as a CD41 reference mAb during HLDA 6.

Form

Size

Format

Part#

Status

Line Quality Standard

FITC

IM0649U A07781 IM1416U 6607117 6607116 6607115 B16894 IM0145

2 mL

Liquid Liquid Liquid Liquid Liquid Liquid Liquid

ASR

IOTest IOTest IOTest IOTest IOTest IOTest IOTest

GMP

PE PE

100 tests

CE

98/79/EC

2 mL

ASR RUO RUO RUO ASR RUO

GMP GMP GMP GMP GMP GMP

ECD PC5 PC7 APC

100 tests 100 tests 100 tests

0.5 mL 0.2 mg

UNLB

Freeze-dried

-

Clone: SZ22 Isotype: IgG1 Mouse The SZ22 monoclonal antibody reacts with the α chain of CD41 (GPIIb α ) on platelets and megakaryocytes. This monoclonal does not inhibit platelet aggregation and secretion induced by collagen, arachidonic acid, and thrombin. It does not inhibit fibrinogen binding to human platelets induced by ADP, arachidonic acid and PAF.

Form

Size

Format

Part#

Status

Line Quality Standard

FITC

IM1756U

2 mL

Liquid

ASR

IOTest

GMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 59 Outside US Flow Cytometry Catalog