Flow Cytometry catalog - ROW 2019

Single-Color Conjugated Antibodies

CD1a is a member of the lipid antigen presenting molecules family Like the other CD1 proteins (group 1: CD1a, CD1b, CD1c and group 2: CD1d, CD1e), CD1a is a transmembrane protein of 49 kDa, noncovalently associated with β 2-microglobulin. As other group 1 CD1 antigens, CD1a is found on professional antigen-presenting cells (APC) such as dendritic cells, particularly on Langerhans cells and their direct circulating precursors. It is expressed by those cells related to dermal dendritic cells, derived from monocytes cultured for 6 days in the presence of GMCSF and IL-4. The CD1a antigen is also present on a B cell subset. It is also strongly expressed by cortical thymocytes. CD1a antibodies are useful in the definition of the thymic stage of T cells. CD1a

MOLT4 cell line

Clone: SFCI19Thy1A8 (T6)

Isotype: IgG1 Mouse

T6 (ref 6T-CD1.7) was used as a CD1a reference monoclonal antibody during HLDA 6.

Form

Size

Format

Part#

Status

Line Quality Standard

RD1

6603185

100 tests

Liquid

RUO

GMP

COULTER CLONE

Clone: BL6

Isotype: IgG1 Mouse

The BL6 antibody recognizes the C epitope of the CD1a molecule.

Form

Size

Format

Part#

Status

Line Quality Standard

FITC

B25330 A07742 IM1942U IM3610 IM3645

1 mL

Liquid Liquid Liquid Liquid Liquid

ASR

IOTest IOTest IOTest IOTest IOTest

GMP

PE PE

100 tests

CE

98/79/EC

2 mL 1 mL 1 mL

ASR ASR ASR

GMP GMP GMP

PC5 APC

The CD1c antigen (also called BDCA-1) is a member of the CD1 family of proteins that are structurally related to MHC class I proteins. CD1c is a membrane glycoprotein with a molecular weight of 43 kDa, non-covalently associated with β 2-microglobulin. CD1c antigen is expressed on a major subpopulation of human myeloid dendritic cells. In blood, CD1c is also expressed on a subpopulation of CD19+ small resting B lymphocytes. Its expression has also been detected on cortical thymocytes (weakly), on Langerhans cells and on dendritic cells. CD1c+ myeloid dendritic cells have been designated as type-1 myeloid dendritic cells (MDC1s). It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule. CD1c

Lysed normal whole blood sample.

Form Clone: L161

Isotype: IgG1 Mouse

Size

Format

Part#

Status

Line Quality Standard

PC5.5

B46036

0.5 mL

Liquid

ASR

IOTest

GMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 30 Outside US Flow Cytometry Catalog