Flow Cytometry catalog - ROW 2019

Single-Color Conjugated Antibodies

ROR1

ROR1, the Receptor tyrosine kinase-like orphan receptor 1, is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. RORs are classified as pseudokinases lacking detectable catalytic activity. They are highly homologous in humans and mice. ROR1 and ROR2 are composed of a distinguished extracellular region with one immunoglobulin domain, one frizzled domain, and one kringle domain, followed by a transmembrane region and an intracellular region that contains a tyrosine kinase domain. ROR1 stands out for its selective and high expression in numerous blood and solid malignancies compared with a minimal expression in healthy adult tissues. Current understanding attributes a survival role for ROR1 in cancer cells; however, its oncogenic function is cancer-type-specific and involves various signaling pathways.

CA46 Cell Line

Clone: 2A2 Isotype: IgG1 Mouse Epitope mapping studies showed that the 2A2 clone recognized N-terminal epitopes in the extracellular region of ROR1.

Form

Size

Format

Part#

Status

Line Quality Standard

PE

B68136

1 mL

Liquid

ASR

IOTest

GMP

Human T cells recognize foreign antigens, in the context of host HLA molecules through the T- cell receptor for antigen (TcR). The TcRs are molecular complexes which comprise two units: a recognition unit, composed of either α - β or γ - δ heterodimer, which are present on the cell surface in a mutually exclusive manner, and, a transducing unit, the CD3 complex, common to α - β and γ - δ heterodimers, which triggers the T cell when the recognition unit is occupied by the antigen. The recognition units recognize any possible foreign antigen and the diversity necessary for this function of recognition is generated by somatic recombination the TcR genes. There are four TcR gene loci ( α , β , γ and δ ). Each of them is composed of several V (for variable) segments, coding for about 90 amino acids, very short D (for diversity) segments ( α and δ loci only), and short J (for joining) segments (about 15 amino acids), and one or two C (for constant) segments. TCR PAN α / β

Lysed normal whole blood sample.

Clone: IP26A

Isotype: IgG1 Mouse

Form The IP26A antibody recognizes a monomorphic determinant of the human α / β chain of the TcR complex. Part# Format Size Status

Line Quality Standard

PE PE

A39499 B49177 A39500 B13981

1 mL

Liquid Liquid Liquid Liquid

ASR

IOTest IOTest IOTest IOTest

GMP

50 tests 0.5 mL 0.5 mL

CE

98/79/EC

PC5 APC

ASR ASR

GMP GMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 126 Outside US Flow Cytometry Catalog