Flow Cytometry catalog - ROW 2019

Single-Color Conjugated Antibodies

The CD243 antigen (P-gp) is the 170-180 kDa multi-drug resistance (mdr)-1 gene product. This protein carries out ATP-dependent efflux of structurally diverse lipophilic compounds, including many anti-cancer chemotherapy agents. In hematopoietic cells, the mdr1 gene product is expressed, but at relatively low levels. P-gp is expressed in specialized epithelial cells with secretory or excretory functions. In the liver, P-gp is found on the biliary surface of hepatocytes and small biliary ductules; in the pancreas, on the laminal surface of epithelial cells of small ductules and, in the kidney, on the brush border of the proximal tubules. Additional sites of expression include the gastrointestinal tract, endothelial cells of the brain and the adrenal glands. CD243 ( P-glycoprotein )

Lysed normal whole blood sample.

Clone: UIC2 Isotype: IgG2a Mouse The UIC2 antibody reacts with an external epitope of the human P-glycoprotein (P-gp). UIC2 antibody inhibits Pgp- mediated efflux and potentiates the cytotoxic action of P-gp transported drugs in MDR cells.

Form

Size

Format

Part#

Status

Line Quality Standard

PE

IM2370U

2 mL

Liquid

ASR

IOTest

GMP

The CD244 antigen, also called 2B4, is a 38 kDa cell surface signal transduction molecule found on almost all human NK cells. It induces a granule independent killing mechanism by NK effector cells. It is also found on γδ TCR T cells and appoximately half of peripheral αβ TCR CD8+ T cells. It is not found on B or naïve CD8+ T cells. Upon activation, most CD8+ T cells become CD244-positive. However, a small but significant minority of CD8+ T cells remain CD244-negative. This subset is associated with lower cytotoxic activity, lower γ -IFN production and higher IL-4 and IL-10 production. CD244 is a high affinity receptor for CD48. CD244 ( 2B4 )

Lysed normal whole blood sample.

Form Clone: C1.7

Isotype: IgG1 Mouse

Size

Format

Part#

Status

Line Quality Standard

PE

IM1608 B21171

2 mL

Liquid Liquid

ASR ASR

IOTest IOTest

GMP GMP

PC5.5

0.5 mL

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 104 Outside US Flow Cytometry Catalog