2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

CD144, also called Cadherin 5, CDH5 or VE-Cadherin is a 140 kDa protein belonging to the cadherin family of cell adhesion molecules which interact homophilically in trans and form lateral interactions in cis. VE-cadherin is the major component of endothelial adherens junctions and is specific to endothelial cells. It is present in all endothelial cells of all types of vessels. It is located at the intercellular cleft sites of the junction within endothelial tissue. CD144 cannot be found in any other cell type, including blood cells or hemopoietic stem cells, and, like a signature for the endothelium, is expressed during development, when cells become committed to the endothelial lineage. The cadherin 5 molecule may play a role in the permeability properties of vascular endothelium. CD144 ( VE-Cadherin )

HUVEC Cell line.

Clone: TEA 1/31 (IgG1 Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

PE

A07481

2 mL

Liquid

ASR

IOTest

cGMP

CD146

The CD146 molecule, also known as S-Endo, is a single chain transmembrane glycoprotein with a molecular weight of 118 kDa, belonging to the immunoglobulin superfamily (IgS). The extracellular structure consists of five Ig-like domains: two V- type, and three C2-type Ig-like domains. The CD146 antigen is related to cell adhesion molecules of the IgS family and its presence is concentrated at regions of cell-cell contact, confirming its role in adhesion and particularly in maintenance of monolayer integrity. CD146 is constitutively expressed in the endothelium, and is also observed on other cell types such as smooth muscle cells, and intermediate trophoblasts. Among peripheral whole blood leucocytes, CD146 expression is not detected, except on a subset of activated T-lymphocytes.

HELA Cell line.

Clone: TEA 1/34 (IgG2a Mouse) The TEA 1/34 monoclonal antibody was assigned to the CD146 (Code: E077) during the HLDA 6.

Form

Format

Part#

Status

Line

Quality Standard

Size

PE

A07483 A22364

2 mL 1 mL

Liquid Liquid

ASR ASR

IOTest IOTest

cGMP cGMP

PC5

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 90 Outside US Flow Cytometry Catalog