2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

CD138

The CD138 antigen (also known as syndecan-1) is a member of the syndecan family, which is comprised of 4 types of transmembrane heparan sulfate proteoglycans macromolecules (syndecan-1, -2 or fibroglycan, -3 or N-syndecan, and -4 or amphiglycan). These molecules are involved in interactions with extracellular matrix proteins, with cell-surface molecules and with soluble proteins such as cytokines. CD138 expression in human hematopoietic cells is restricted to plasma cells in normal bone marrow. Peripheral blood monocytes, T- and B-lymphocytes are not reactive. Tonsil cells and early B-cell precursors in human bone marrow also are negative. CD138 is expressed in a variety of mature tissues, including epithelial cells, endothelial cells, fibroblasts, keratinocytes and normal hepatocytes. CD138 may act as an essential regulator of ligand-specific activation of primary signalling receptors at the cell surface, by co-engagement of various accessory ligands.

U266B1 cell line.

Clone: B-A38 (IgG1 Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

PB

B37788 B42019 A54190 A40316 A54191 A40317 B96786 A98835 B49219 A87787

0.5 mL 0.5 mL

Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid

ASR ASR

IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest

cGMP cGMP

KrO

PE PE

100 tests

CE/IVD

98/79/EC

2 mL

ASR

cGMP

PC5 PC5

100 tests

CE/IVD

98/79/EC

1 mL

ASR

cGMP

PC5.5 PC5.5

50 tests 0.5 mL 50 tests 0.5 mL

CE/IVD

98/79/EC

ASR

cGMP

APC APC

CE/IVD

98/79/EC

ASR

cGMP

CD141, also known as thrombomodulin (TM) and BDCA-3, is an endothelial cell surface receptor. It is a 75 kD type I membrane glycoprotein and members of C-type lectin family. Two major isoforms exist, differentiated by the presence or not of sulfated glycosaminoglycan at Ser/Thr region. CD141 antigen is expressed on neutrophils, monocytes and platelets. CD141 is expressed at high levels on a minor subpopulation of human myeloid dendritic cells that show monocytoid morphology. This subpopulation of dendritic cells is of special interest, because it has an influence on regulatory T cells and hence on immune responses. CD141 is also expressed by vascular endothelial cells, and keratinocytes. It is a cofactor in the activation of protein C and initiation of the protein C anticoagulant pathway by binding to its ligand thrombin. CD141 ( BDCA-3 )

Overlay - CD141-FITC K562 Transfected cell line.

Clone: M80 (IgG1 Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC

B43289

1 mL

Liquid

ASR

IOTest

cGMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 89 Outside US Flow Cytometry Catalog