2020 Outside US Flow Cytometry Catalog

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Single-Color Conjugated Antibodies

The CD135 antigen, also called FLT3 or FLK2 or STK1, is an integral transmembrane glycoprotein of 130 kDa to 150 kDa, which belongs to the class III receptor tyrosine kinase (RTK) family. These receptors directly bind extracellular ligands and transduce regulatory signals through intracytoplasmic tyrosine kinase activity. The CD135 antigen is expressed on myelomonocytic and primitive B cell progenitors. On normal bone marrow cells, expression of CD135 can be found on CD34-positive as well as CD34-negative cells. Most of the CD34bright, CD135-positive cells co-express CD117 at high levels. They may represent early cycling, not quiescent stem cells. CD135- positive cells in the CD34 low and CD34-negative populations do not co-express CD117 molecule and may represent B-lymphoid precursors. CD135 ( flt3/flk2 )

JEA2 Cell line.

Clone: SF1.340 (IgG1 Mouse) The SF1.340 antibody is specific for an extracellular domain of CD135. This antibody does not compete with the FLT3 ligand for binding to FLT3.

Form

Format

Part#

Status

Line

Quality Standard

Size

IM2234U

2 mL

Liquid

ASR

IOTest

cGMP

CD137

CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family. CD137 is expressed on activated T and B cells, NK cells, monocytes and follicular dendritic cells. Differential splicing leads to the release of a 16-kDa soluble from activated T cells. CD137 is involved in monocyte activation by inducing an increase in the production of IL-6, IL-8 and TNF- α , and an inhibition of IL-10 production. In addition, CD137 plays a role in the induction of B lymphocyte apoptosis and the co-stimulation of T-cell proliferation.

Lysed normal whole blood sample.

Clone: 4B4-1 (IgG1 Mouse)