2020 Outside US Flow Cytometry Catalog

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Single-Color Conjugated Antibodies

CD133

CD133, also known as AC133 or PROML1, is a 5-transmembrane glycoprotein of 120kDa belonging to the prominin family. It is mainly expressed on primitive cell populations such as CD34 hematopoietic stem and progenitor cells, neural and endothelial stem cells. In association with CD309 (KDR or VEGFR-2), CD133 allows the specific detection of endothelial progenitor cells. CD133 function is unknown although a naturally occurring mutation is associated with degenerative disease in the retina of affected patients.

Y79 cell line.

Clone: W6B3C1 (IgG1 Mouse) The clone W6B3C1was assignedto CD133 during the SeventhHLDAWorkshopon HumanLeukocyteDifferentiationAntigens.Similarlyto AC133/1clone, it recognizes the epitope 1.

Form

Format

Part#

Status

Line

Quality Standard

Size

APC

C15190

0.5 mL

Liquid

ASR

IOTest

cGMP

The CD134 antigen is a 35 kDa, type-1 transmembrane glycoprotein member of the tumor necrosis factor superfamily (TNFRSF) and is allocated number 4. This antigen was originally named OX40 from the first antibody that led to the discovery of this antigen on activated rat CD4+ T cells. In humans, CD134 is expressed at high levels on activated CD4+ T cells and virally stimulated CD4+ T cells. Its ligand, known as gp34, is a type-2 transmembrane glycoprotein member of the tumor necrosis factor (TNF) superfamily, expressed on activated T and B cells, dendritic cells and macrophages. The CD134 antigen, through its interaction with adaptor proteins TRAF2, TRAF3 and TRAF5, is a costimulatory signal transducer of T-cell receptor-mediated activation that has been shown to activate NF- κ B, a signaling factor involved in transcription of survival genes. Thus, CD134 engagement with its ligand induces clonal expansion and survival of CD4+ cells during primary responses, and results in the accumulation of increasing numbers of memory cells with time. Finally, CD134 has been shown to be involved in the T cell adhesion to endothelium. CD134 ( OX 40 )

Lysed normal whole blood sample.

Clone: Ber-ACT35 (IgG1 Mouse) Ber-ACT35 cross reacts with: Feline.