2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

CD59

The CD59 antigen, also known as Protectin or Membrane Inhibitor of Reactive Lysis (MIRL) is a 18-20 kDa, single-chain, glycosylphosphatidylinositol (GPI)-anchored cell surface protein. CD59 inhibits complement lysis by binding to the C5b-8 and C5b-9 complexes and thus preventing formation of the polymeric C9 complex during the final steps of membrane attack complex (MAC). CD59 is expressed on all haematopoietic cells and is widely expressed on cells in all tissues. Studies of the susceptibility of HIV-1, HTLV-1 and HCMV to complement (C)-mediated lysis suggest that viruses incorporate host cell-derived C regulatory proteins such as CD59 and CD55, a mechanism by which a variety of enveloped viruses may acquire resistance to C-mediated lysis.

Lysed normal whole blood sample.

Clone: P282E (IgG2a Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC FITC

B49187

100 tests

Liquid Liquid

CE/IVD

IOTest IOTest

98/79/EC

IM3457U

2 mL

ASR

cGMP

Clone: MEM-43 (IgG2a Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

PE

B68140

1 mL

Liquid

ASR

IOTest

cGMP

CD61

The CD61 antigen (platelet glycoprotein GPIIIa) is the 110 kDa integrin β 3 subunit, con- covalently associated with the integrin α IIb chain (CD41, platelet GPIIb) to form the GPIIb-IIIa complex ( α IIb- β 3 integrin). Independently of CD41, CD61 is also associated with the integrin α V (CD51) to form the vitronectin receptor. CD41/CD61 is expressed only by platelets and megakaryocytes, whereas CD51/CD61 is found on osteoclasts, endothelial cells, macrophages, fibroblasts, smooth muscle, synovial lining cells and renal glomeruli.

Platelet rich plasma (PRP) from a normal whole blood sample.

Clone: SZ21 (IgG1 Mouse) The SZ21 antibodyis specificfor the PlA1, not the PlA2 formof GPIIIa.It inhibitsplateletaggregationand secretioninducedby collagen,arachidonicacid, and thrombin. This antibody also inhibits fibrinogen binding to human platelets induced by ADP, arachidonic acid and PAF.

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC FITC

IM1758

100 tests

Liquid Liquid Liquid Liquid Liquid

CE/IVD

IOTest IOTest IOTest IOTest IOTest

98/79/EC

IM1758U IM3605 B21172 IM3716 IM0540

2 mL 2 mL

ASR ASR ASR ASR RUO

cGMP cGMP cGMP cGMP cGMP

PE

PC5.5

0.5 mL

PC7

1 mL

UNLB

0.2 mg

Freeze-dried

-

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 69 Outside US Flow Cytometry Catalog