2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

CD49e

The CD49e antigen is the 160 kDa integrin α 5-chain, which is composed of a heavy chain (135 kDa) and a light chain (25 kDa), linked by a disulfide bond. CD49e is non- covalently associated with the 130 kDa integrin β 1-chain (CD29 molecule), forming the VLA-5 complex. CD49e is expressed by monocytes, platelets and two myeloid cell lines (U937, K562). It is known as the fibronectin and invasin receptor. It is useful for basic studies of fibronectin-mediated adhesion.

Lysed normal whole blood sample.

Clone: SAM1 (IgG2b Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC

IM1854U

2 mL

Liquid

ASR

IOTest

cGMP

CD52

CD52, also called CAMPATH-1, is a 21-28 kDa glycopeptide anchored to the membrane by a glycosylphosphatidylinositol (GPI) structure. The mature CD52 antigen is a very small protein (12 aminoacids) of 8-9 kDa. CD52 is expressed on lymphocytes, monocytes, macrophages and on epithelial cells of male reproductive tract, shed into seminal plasma and acquired by spermatozoa. Physiological role of CD52 on lymphocytes is unclear, although CAMPATH-1 antibody is capable of complement activation and it has been used in lympho proliferative disorders. Monoclonal antibodies directed against sperm may cause sperm immobilization and agglutination.

Lysed normal whole blood sample.

Clone: HI186 (IgG2b Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

PC7

B68152

0.5 mL

Liquid

ASR

IOTest

cGMP

CD54

The CD54 antigen, previously known as ICAM-1 (InterCellular Adhesion Molecule-1), is a 90 kDa transmembrane glycoprotein. With seven potential N-linked glycosylation sites, its structure, as that of CD50 (ICAM-3) and CD102 (ICAM-2), is related to the Immunoglobulin family. The CD54 antigen mediates the adhesion of T lymphocytes with Antigen-Presenting Cells (APC) and is involved in T cell to T cell and T cell to B cell interactions. It is also involved in the adhesion of monocytes, lymphocytes and neutrophils to activated endothelium. It binds to the integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It is a receptor for the rhinovirus. It is expressed by endothelial cells and by many other cell types upon activation.

Lysed normal whole blood sample.

Clone: 84H10 (IgG1 Mouse) 84H10 antibody inhibits ICAM-1 mediated adhesion to LFA-1. 84H10 cross reacts with: Canine.

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC

IM0726U IM1239U

2 mL 2 mL

Liquid Liquid

ASR ASR

IOTest IOTest

cGMP cGMP

PE

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 66 Outside US Flow Cytometry Catalog