2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

CD41

The CD41 antigen (platelet GPIIb; IIb integrin) is a transmembrane glycoprotein composed of two chains GPIIb α (120 kDa) and GPIIb β (23 kDa) linked by one disulfide bond. CD41 is always non-covalently associated with CD61 (platelet GPIIIa, β 3 integrin), to form the GPIIb-IIIa (CD41/CD61) complex. CD41 is expressed by platelets, megakaryocytes and a small subset of CD34+ cells, suggesting that CD41/CD61 is one of the earliest markers of the megakaryocytic lineage. The resting form of the CD41/CD61 complex binds to immobilized fibrinogen and upon platelet activation, the complex becomes a receptor for soluble fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. It is involved in platelet aggregation.

HEL cell line.

Clone: P2 (IgG1 Mouse) The P2 antibodyreactswith the α chain of CD41a(GPIIb α ) in the intactcomplexwith GPIIIabut not with the GPIIb or GPIIIaseparately.This antibodyblocks bindingto fibrinogenandinhibitsplateletaggregationinducedby thrombin,collagenandADP.TheP2 antibodywasusedas a CD41referencemAbduringHLDA 6.

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC

IM0649U A07781 IM1416U 6607117 6607116 6607115 B16894 IM0145

2 mL

Liquid Liquid Liquid Liquid Liquid Liquid Liquid

ASR

IOTest IOTest IOTest IOTest IOTest IOTest IOTest

cGMP

PE PE

100 tests

CE/IVD

98/79/EC

2 mL

ASR RUO RUO RUO ASR RUO

cGMP cGMP cGMP cGMP cGMP cGMP

ECD PC5 PC7 APC

100 tests 100 tests 100 tests

0.5 mL 0.2 mg

UNLB

Freeze-dried

-

Clone: SZ22 (IgG1 Mouse) The SZ22monoclonalantibodyreactswiththe

α chainof CD41(GPIIb α ) on plateletsandmegakaryocytes.Thismonoclonaldoesnot inhibitplateletaggregation andsecretioninducedby collagen,arachidonicacid,andthrombin.It doesnot inhibitfibrinogenbindingto humanplateletsinducedby ADP,arachidonicacidand PAF.

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC

IM1756U

2 mL

Liquid

ASR

IOTest

cGMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 59 Outside US Flow Cytometry Catalog