2020 Outside US Flow Cytometry Catalog
Single-Color Conjugated Antibodies
CD39
The CD39 molecule, known as ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), is a 70-100 kDa integral membrane glycoprotein with two transmembrane domains. It belongs to the family of the primary enzymes responsible for cell surface nucleotide hydrolysis, with ATPase and ADPase activity. CD39 antigen is expressed on activated lymphocytes, regulatory T cells, B cells, and dendritic cells. It is involved in control of the extracellular nucleoside triphosphate pool (NTP), suppression of inflammation and control of platelet activation. The coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops. In human studies, it has been reported that CD4 +CD25-CD39+ T cells are T inducers.
Lysed normal whole blood sample.
Clone: BA54 (IgG1 Mouse)
Form
Format
Part#
Status
Line
Quality Standard
Size
PE
B55384 B55385
1 mL
Liquid Liquid
ASR ASR
IOTest IOTest
cGMP cGMP
PC5.5
0.5 mL
CD40
The CD40 antigen is a 44-48 kDa type I integral membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. This antigen is found on B cell lines, is strongly expressed by interdigitating cells (IDC), basal epithelial cells, and is also present on macrophages, some endothelial cells, and follicular dendritic cells. It is a pan-B marker, absent only from terminally differentiated plasma cells. CD40 is implicated in the process of B cell selection in the germinal centre. Studies demonstrated that CD40 monoclonal antibodies (mAbs) induce strong homotypic adhesions in resting B cells and, together with interleukin-4 (IL-4) maintain the cell cycle of blasts of the B lineage. They also can promote the switch to IgE secretion. Activated B cells via CD40 antigen in the presence of IL-10 differentiate into plasma cells and secrete large amounts of immunoglobulins. The CD154, (CD40 ligand) is a membrane glycoprotein on activated T cells that induces B cell proliferation and immunoglobulin secretion. CD154 is also expressed on activated platelets and triggers an inflammatory reaction of endothelial cells.
Lysed normal whole blood sample.
Clone: MAB89 (IgG1 Mouse) Co-culture with MAB89 and IL-4 leads to long term B cell proliferation.
Form
Format
Part#
Status
Line
Quality Standard
Size
PE
IM1936U B20025 B30636
2 mL
Liquid Liquid Liquid
ASR ASR ASR ASR
IOTest IOTest IOTest
cGMP cGMP cGMP cGMP
PC5.5
0.5 mL 0.5 mL 0.2 mg
APC
UNLB
IM1374
Freeze-dried
-
If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 58 Outside US Flow Cytometry Catalog
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