2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

Along with CD8 α , the CD8 β polypeptide molecule is one of the two chains which can be expressed within the CD8 dimer. CD8 α is required for surface expression of CD8 β . The α and β glycoproteins have similar molecular weights of 32-34 kDa each. They form homodimeric (CD8 α / α ) or heterodimeric (CD8 α / β ) cell surface complexes. Most of human peripheral T cells express CD8 as an α / β heterodimer. NK cells and a proportion of TCR γ / δ T cells express CD8 as an α / α homodimer. CD8 β surface expression requires the surface expression of CD8 α . Consequently, CD8 α can form homodimer but CD8 β cannot. CD8 β

Lysed normal whole blood sample.

Form Clone: 2ST8.5H7 (IgG2a Mouse) The 2ST8.5H7 monoclonal antibody reacts with an epitope formed by the combination of the α and β polypeptides. Part# Format Size Status Line

Quality Standard

FITC

B42025 IM2217U 6607123 IM2014

1 mL 2 mL

Liquid Liquid Liquid

ASR ASR RUO RUO

IOTest IOTest IOTest

cGMP cGMP cGMP cGMP

PE

ECD

100 tests

UNLB

0.2 mg

Freeze-dried

-

CD9

CD9 (p24 antigen) is a single transmembrane polypeptide of 24 kDa related to the tetraspanin (TM4) family. Like other tetraspanins (e.g. CD63, CD81, CD82, CD37, CD53, among the 20 known members), CD9 structure is composed of 4 transmembrane domains, with intracellular N and C termini. First discovered on a lymphoblastic cell line of pre-B phenotype, CD9 was then found on platelets and within their α -granules, on monocytes, pre-B cells, eosinophils, basophils and activated T cells. The CD9 molecule associates with other surface proteins such as the α 6/ β 4 integrin (CD49f/CD104 molecule) and HLA-DR, suggesting a role in adhesion, signal transduction and cell motility.

Platelet-rich plasma (PRP) from normal whole blood.

Clone: ALB6 (IgG1 Mouse) The ALB6monoclonalantibody(mAb)was first reportedas specificfor CD9 (p24)on platelets,capableof modulatingaggregationof plateletsactivatedwith various agonists.

Form

Format

Part#

Status

Line

Quality Standard

Size

PB

B09979 IM1755U B13649

0.5 mL

Liquid Liquid Liquid

ASR ASR ASR RUO

IOTest IOTest IOTest

cGMP cGMP cGMP cGMP

FITC

2 mL

APC-A750

0.5 mL 0.2 mg

UNLB

IM0117

Freeze-dried

-

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 37 Outside US Flow Cytometry Catalog