2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

CD4

The CD4 antigen is a monomeric transmembrane glycoprotein with a molecular weight of 59 kDa. The intracytoplasmic tail of CD4 is essential for interaction with Lck. The CD4 is expressed on the T "helper" (Th or T4) lymphocytes. It is expressed on most thymocytes, where it is frequently co-expressed with CD8. CD4 is also expressed on eosinophils. All the monocytes carry the CD4 antigen, but at a lower density than T4 lymphocytes. CD4 acts as an accessory molecule to the T cell receptor complex during T-cell activation restricted to the major histocompatibility complex class II. The T4 lymphocytes are involved in T-T, T-B, and B-macrophage cellular interactions. They are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 functions as the receptor for IL-16 which is a chemoattractant factor for CD4+ T cells, as well as for monocytes and eosinophils. IL -16 seems to be a growth factor for T4 lymphocytes, but is not able to induce cell division. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120.

Lysed normal whole blood sample.

Clone: 13B8.2 (IgG1 Mouse) 13B8.2monoclonalantibodyantagonizesHIVeffects cross reacts with: Hamadyras Baboon, Olive Baboon.

in vitro . 13B8.2recognizesan epitopecloseto theamino-acidresidues88-89withintheCD4molecule.13B8.2

Form

Format

Part#

Status

Line

Quality Standard

Size

PB PB

B49197 A82789 A96417 A07750 IM0448U IM0449U A07752 IM2636U B16491 IM2468 IM2468U B10824 A94682 A94685 IM0704 IM0398 A07751

50 tests 0.5 mL 0.5 mL 100 tests

Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid Liquid

CE/IVD

IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest IOTest

98/79/EC

ASR ASR

cGMP cGMP

KrO FITC FITC

CE/IVD

98/79/EC

2 mL

ASR

cGMP

PE PE

100 tests

CE/IVD

98/79/EC

2 mL

ASR

cGMP

PC5 PC5

100 tests

CE/IVD

98/79/EC

1 mL

ASR ASR

cGMP cGMP

PC5.5

0.5 mL

APC APC

100 tests

CE/IVD

98/79/EC

1 mL

ASR ASR

cGMP cGMP

APC-A700 APC-A750 APC-A750

0.5 mL 50 tests 0.5 mL 0.2 mg 0.2 mg

CE/IVD

98/79/EC

ASR ASR ASR

cGMP cGMP cGMP

Biotin UNLB

Freeze-dried Freeze-dried

- -

Clone: SFCI12T4D11 (IgG1 Mouse) SFCI12T4D11 monoclonal antibody antagonizes HIV effects in vitro . SFCI12T4D11 cross reacts with: Hamadyras Baboon, Olive Baboon.

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC FITC RD1 RD1 ECD PC7 PC7

6602393 6603862 6602864 6603850 6604727 6607101 737660

100 tests 50 tests 100 tests 50 tests

Freeze-dried

IVD IVD IVD IVD ASR RUO

cGMP cGMP cGMP cGMP cGMP cGMP

COULTER CLONE

Liquid Liquid Liquid Liquid Liquid Liquid

CYTO - STAT

COULTER CLONE

CYTO - STAT CYTO - STAT

0.5 mL

100 tests 100 tests

IOTest IOTest

CE/IVD

98/79/EC

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 33 Outside US Flow Cytometry Catalog