2020 Outside US Flow Cytometry Catalog
Single-Color Conjugated Antibodies
ROR1
ROR1, the Receptor tyrosine kinase-like orphan receptor 1, is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. RORs are classified as pseudokinases lacking detectable catalytic activity. They are highly homologous in humans and mice. ROR1 and ROR2 are composed of a distinguished extracellular region with one immunoglobulin domain, one frizzled domain, and one kringle domain, followed by a transmembrane region and an intracellular region that contains a tyrosine kinase domain. ROR1 stands out for its selective and high expression in numerous blood and solid malignancies compared with a minimal expression in healthy adult tissues. Current understanding attributes a survival role for ROR1 in cancer cells; however, its oncogenic function is cancer-type- specific and involves various signaling pathways.
CA46 Cell Line.
Clone: 2A2 (IgG1 Mouse) Epitope mapping studies showed that the 2A2 clone recognized N-terminal epitopes in the extracellular region of ROR1.
Form
Format
Part#
Status
Line
Quality Standard
Size
PE
B68136
1 mL
Liquid
ASR
IOTest
cGMP
Human T cells recognize foreign antigens, in the context of host HLA molecules through the T-cell receptor for antigen (TcR). The TcRs are molecular complexes which comprise two units: a recognition unit, composed of either α - β or γ - δ heterodimer, which are present on the cell surface in a mutually exclusive manner, and, a transducing unit, the CD3 complex, common to α - β and γ - δ heterodimers, which triggers the T cell when the recognition unit is occupied by the antigen. The recognition units recognize any possible foreign antigen and the diversity necessary for this function of recognition is generated by somatic recombination the TcR genes. There are four TcR gene loci ( α , β , γ and δ ). Each of them is composed of several V (for variable) segments, coding for about 90 amino acids, very short D (for diversity) segments ( α and δ loci only), and short J (for joining) segments (about 15 amino acids), and one or two C (for constant) segments. TCR PAN α / β Clone: IP26A (IgG1 Mouse) The IP26A antibody recognizes a monomorphic determinant of the human α / β chain of the TcR complex. Part# Format Size Status Form
Lysed normal whole blood sample.
Line
Quality Standard
PE PE
B49177 A39499 A39500 B13981
50 tests
Liquid Liquid Liquid Liquid
CE/IVD
IOTest IOTest IOTest IOTest
98/79/EC
1 mL
ASR ASR ASR
cGMP cGMP cGMP
PC5 APC
0.5 mL 0.5 mL
If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 125 Outside US Flow Cytometry Catalog
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