2020 Outside US Flow Cytometry Catalog
Single-Color Conjugated Antibodies
OSCAR
OSCAR, an abbreviation of osteoclast-associated receptor, is a new member of the leukocyte receptor complex. Human OSCAR is a cell-surface, monomeric N- glycosylated protein of approximately 45 kDa. The amino acid sequence shows homology with that of members of the KIR family. The protein exhibits two C2-type immunoglobulin extracellular domains, a transmembrane section that contains a positively charged arginine residue, and a short intracytoplasmic tail with no recognizable signaling motif. As suggested by the presence of the charged residue, OSCAR associates with the ITAM-adapter FcR γ and not with other signaling molecules. The gene coding for OSCAR has been mapped to chromosome 19q13. Unlike mouse OSCAR, human OSCAR is widely expressed in cells of the myeloid lineage, and in particular, at all stages of dendritic cell (DC) differentiation and maturation. T cells, B cells, and NK cells do not express OSCAR. OSCAR is involved in antigen presentation and activation of human DCs. It allows processing and presentation of exogenous antigens.
Lysed normal whole blood sample.
Clone: 11.1CN5 (IgG1 Mouse)
Form
Format
Part#
Status
Line
Quality Standard
Size
PE
A24987
100 tests
Liquid
RUO
IOTest
cGMP
Perforin
Perforin is a 70 kD N-glycosylated modified cytolytic protein. Following synthesis and post-translational modifications, perforin monomers are packaged into lysosome-like cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Both types of cells kill their cellular targets by mechanisms that require direct contact between the effector and target cells. Cytoplasmic granule toxins, predominantly perforin, and a family of structurally related serine proteases (granzymes) with various substrate specificities are secreted by exocytosis and together induce apoptosis of the target cell. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.
Lysed normal whole blood sample.
Clone: dG9 (IgG2b Mouse)
Form
Format
Part#
Status
Line
Quality Standard
Size
PB
B46030
0.5 mL
Liquid
ASR
IOTest
cGMP
If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 124 Outside US Flow Cytometry Catalog
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