2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

Human melanoma-associated chondroitin suflate proteoglycan (MCSP), known as the homolog rat NG2 antigen, is a 250 kDa glycoprotein that is though to play important roles in angiogenesis-dependent processes like wound healing and tumor growth. The core protein contains an open frame of 2322 amino acids encompassing a large extracellular domain, a hydrophobic transmembrane region and a relatively short cytoplasmic tail. This antigen is not expressed on normal hematopoietic cells but can be expressed on myeloid and lymphoid cell subsets with chromosomal modifications. It is also expressed on human glial cells. This antigen regulates signaling events that are important for both cell proliferation and cell migration through at least two distinct mechanisms: the focal adhesion kinase (FAK) and the extracellular signal- regulated kinases (ERK) 1/2. NG2 ( 7.1 )

HELA cell line.

Clone: 7.1 (IgG1 Mouse) The 7.1 monoclonal antibody recognizes the human melanoma associated chondroitin sulfate proteoglycan molecule.

Form

Format

Part#

Status

Line

Quality Standard

Size

PE PE

B92429 IM3454U

100 tests

Liquid Liquid

CE/IVD

IOTest IOTest

98/79/EC

2 mL

ASR

cGMP

NKp80

The NKp80, also known as killer cell lectin-like subfamily F, member 1 (KLRF1) is a type II transmembrane glycoprotein of 80 kDa and 40 kDa under reducing conditions. It is expressed on NK cells and a subset of T lymphocytes whereas it is not expressed on B lymphocytes, monocytes and granulocytes. The NKp80 antigen is a 231 amino acid protein which belongs to the C-lectin family and is encoded by a gene located on chromosome 12. It is characterized, in its 169 amino acid extracellular domain by 4 glycosylation sites and by two tyrosine residues in its 39 amino acid cytoplasmic domain. The transmembrane domain contains 23 amino acids. The NKp80 molecule binds to the genetically linked receptor AICL which is up-regulated by Toll-like receptor stimulation. NKp80-AICL interaction regulates the immune responses at sites of inflammation by stimulating the release of proinflammatory cytokines.

Lysed normal whole blood sample.

Clone: MA152 (IgG1 Mouse) The monoclonal antibody MA152 recognizes NK cells, a subset of T lymphocytes. It does not react with NK92, NK3.3 and YT cell lines.

Form

Format

Part#

Status

Line

Quality Standard

Size

PE

A52635

1 mL

Liquid

ASR

IOTest

cGMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 123 Outside US Flow Cytometry Catalog