2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

IL-17A

IL17-A is a member of the IL-17 family which is constituted by 6 members (IL-17A to IL -17F). IL-17A is commonly refer to as IL-17 and is produced as a homodimer of about 30 kDa. IL-17A is mainly secreted by a subset of CD4 + T cells, namely the Th17 cells, which are helper cells that are distinct from Th1 and Th2 cells. In addition to Th17 cells, other immune cells such as γδ T cells, CD8+ T cells, NK cells and Innate Lymphoid cells (ILCs) can be activated to secrete IL-17. IL-17 is a pro-inflammatory molecule that induces the production of chemokines and other cytokines by various cell types, i.e fibroblasts, epithelial cells, endothelial cells, macrophages and neutrophils, which helps the recruitment of innate immune cells at the site of activation.

Peripheral blood lymphocytes (PBL) activated with PMA/Ionomycin/Brefeldin A, permeabilized and fixed with PerFix-nc reagent.

Clone: BL168 (IgG1 Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

PB

B76266 B90428

50 tests 50 tests

Liquid Liquid

RUO RUO

IOTest IOTest

cGMP cGMP

AF700

Kappa ( κ ) chain is a 25Kd polypeptide that results from papain cleavage of the IgG molecule, encoded by the human immunoglobulin kappa locus (IGK) on chromosome 2. The subunit structure of IgG comprises 2 light chains and 2 heavy chains. Each light chain is composed of two tandem immunoglobulin domains: a) one variable domain (VL) and b) one constant (CL) domain. While the VL show considerable sequence diversity the CL shows internal homology with repeating units. Anti-Kappa antibodies recognize the Kappa light chain of immunoglobulins expressed at the surface of a cellular subpopulation corresponding to approximately 2/3 of mature B lymphocytes in peripheral blood. This light chain is also found on the surface of a sub-population of immature bone marrow B lymphocytes. κ Chain

Lysed normal whole blood sample.

Clone: Polyclonal (F(ab’) 2

Goat)

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC APC

C15623 B90420

2 mL

Liquid Liquid

ASR ASR

IOTest IOTest

cGMP cGMP

0.5 mL

Clone: Polyclonal (F(ab’) 2

Rabbit)

Form

Format

Part#

Status

Line

Quality Standard

Size

FITC FITC

B49178 A64828

100 tests

Liquid Liquid

CE/IVD

IOTest IOTest

98/79/EC

2 mL

ASR

cGMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 120 Outside US Flow Cytometry Catalog