2020 Outside US Flow Cytometry Catalog

Single-Color Conjugated Antibodies

The CD243 antigen (P-gp) is the 170-180 kDa multi-drug resistance (mdr)-1 gene product. This protein carries out ATP-dependent efflux of structurally diverse lipophilic compounds, including many anti-cancer chemotherapy agents. In hematopoietic cells, the mdr1 gene product is expressed, but at relatively low levels. P-gp is expressed in specialized epithelial cells with secretory or excretory functions. In the liver, P-gp is found on the biliary surface of hepatocytes and small biliary ductules; in the pancreas, on the laminal surface of epithelial cells of small ductules and, in the kidney, on the brush border of the proximal tubules. Additional sites of expression include the gastrointestinal tract, endothelial cells of the brain and the adrenal glands. CD243 ( P-glycoprotein )

Lysed normal whole blood sample.

Clone: UIC2 (IgG2a Mouse) TheUIC2antibodyreactswithan externalepitopeof the humanP-glycoprotein(P-gp).UIC2antibodyinhibitsPgp-mediatedeffluxand potentiatesthe cytotoxic action of P-gp transported drugs in MDR cells.

Form

Format

Part#

Status

Line

Quality Standard

Size

PE

IM2370U

2 mL

Liquid

ASR

IOTest

cGMP

The CD244 antigen, also called 2B4, is a 38 kDa cell surface signal transduction molecule found on almost all human NK cells. It induces a granule independent killing mechanism by NK effector cells. It is also found on γδ TCR T cells and appoximately half of peripheral αβ TCR CD8+ T cells. It is not found on B or naïve CD8+ T cells. Upon activation, most CD8+ T cells become CD244-positive. However, a small but significant minority of CD8+ T cells remain CD244-negative. This subset is associated with lower cytotoxic activity, lower γ -IFN production and higher IL-4 and IL-10 production. CD244 is a high affinity receptor for CD48. CD244 ( 2B4 )

Lysed normal whole blood sample.

Clone: C1.7 (IgG1 Mouse)

Form

Format

Part#

Status

Line

Quality Standard

Size

PC5.5

B21171

0.5 mL

Liquid

ASR

IOTest

cGMP

If you require a different antibody fluorochrome combination, please refer to the Custom Design Services on page 14 or contact us via: cds.support@beckman.com ANTIBODIES & KITS 103 Outside US Flow Cytometry Catalog